Anastrozole Arimidex®

Vasomotor and sexual complaints remain problematic, although they occur in only a small proportion of women. However, in one woman who had had amenorrhea for 5 years during tamoxifen treatment the introduction of letrozole in normally accepted doses resulted within 2 weeks in resumption of menstruation [19]. Not discussed in detail in this article is the intrathecal delivery of opioids and other agents to manage otherwise poorly controlled cancer-related pain. This therapy can be helpful in patients who have an expected survival longer than 3 months and who have poorly controlled pain and suffer from opioid-related toxicity.

Do not breastfeed while taking this medication and for 2 weeks after the last dose. Talk to your pediatrician regarding the use of this medicine in children. Anastrozole is also being studied in the treatment of other conditions and types of cancer.

Anastrozole warnings

Anastrozole and letrozole are nonsteroidal, reversible inhibitors of the aromatase enzyme and prevent the conversion of androgens to estrogens (Fig. 36-3). Exemestane differs in that its structure is steroidal in nature, and it irreversibly inhibits the aromatase enzyme. These agents are indicated for first- and second-line hormonal therapy in postmenopausal women with hormone receptor–positive breast cancer. Randomized clinical trials comparing 5years of each of the aromatase inhibitors with 5 years of tamoxifen have demonstrated superior survival rates in postmenopausal women receiving the aromatase inhibitor.

Call your doctor right away if you have a severe allergic reaction to Arimidex. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. As with most drugs, some people can have an allergic reaction after taking Arimidex. But it’s not known how often this occurs in people using Arimidex. Serious side effects from Arimidex aren’t common, but they can occur.

Arimidex Images

Aromatase inhibitor medications can cause joint or muscle aches and pains, which can interfere with the quality of life. Be sure to talk to your oncology care team if you develop this side effect. This pain is caused mainly by swelling in the joints, which is best treated by a non-steroidal anti-inflammatory (NSAID), such as ibuprofen (Advil/Motrin), naproxen (Aleve), and celecoxib (Celebrex).

If you drink alcohol and you’re concerned about how this could affect your breast cancer or its treatment, talk with your doctor. They can give you advice on much alcohol is safe for you to drink. By stopping aromatase from working, Arimidex lowers the amount of estrogen in your body. This helps to stop estrogen from encouraging breast cancer to grow and spread.

These lists contain examples of serious side effects that can occur with Arimidex, with tamoxifen, or with both drugs (when taken individually). These lists contain examples of mild side effects that can occur with Arimidex, with tamoxifen, or with both drugs (when taken individually). If you’d like to know more about taking other where to order genuine steroids in the US drugs with Arimidex, talk with your doctor. If you forget to take a dose of Arimidex, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, just skip the missed dose and take your next dose as usual. If you have heart palpitations while you’re taking Arimidex, call your doctor right away.

Steroidal Versus Nonsteroidal Aromatase Inhibitors

Products containing estrogen (such as birth control pills) should not be used. If you become pregnant or think you may be pregnant, tell your doctor right away. Hot flashes, headache, bone pain, trouble sleeping, dizziness, stomach upset, nausea/vomiting, constipation, diarrhea, loss of appetite, weight gain, tiredness/weakness, increased coughing, or sore throat may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor.


Certain adverse reactions and combinations of adverse reactions were prospectively specified for analysis, based on the known pharmacologic properties and side effect profiles of the two drugs (see Table 2). Anastrozole belongs to a drug class known as aromatase inhibitors which work by blocking the activity of aromatase, an enzyme that plays an important role in the biosynthesis of estrogens, the female sex hormones. The information on this Web site should not take the place of talking with your doctor or health care professional.

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The suppression of estrogen biosynthesis in peripheral tissues and in the cancer tissue itself can therefore be achieved by specifically inhibiting the aromatase enzyme. In animal studies, the drug did cause harm to fetuses when it was given to pregnant females. Keep in mind that animal studies don’t always predict what will happen in humans. However, based on how Arimidex works, it could be harmful to a human fetus if taken during pregnancy. The expiration date helps guarantee that the medication is effective during this time. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications.